MOST PUBLISHED META-REGRESSION ANALYSES BASED ON AGGREGATE DATA SUFFER FROM METHODOLOGICAL PITFALLS: A META-EPIDEMIOLOGICAL STUDY

Most published meta-regression analyses based on aggregate data suffer from methodological pitfalls: a meta-epidemiological study

Abstract Background Due to clinical and methodological diversity, clinical studies included in meta-analyses often differ in ways that lead to differences in treatment effects across studies.Meta-regression analysis is generally recommended to explore associations lin76 between study-level characteristics and treatment effect, however, three key pi

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Interneuron progenitor transplantation to treat CNS dysfunction

Due to the inadequacy of endogenous repair mechanisms diseases of the nervous system remain a major graco ascent challenge to scientists and clinicians.Stem cell based therapy is an exciting and viable strategy that has been shown to ameliorate or even reverse symptoms of CNS dysfunction in preclinical animal models.Of particular importance has bee

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